Author

Ostap A. Dregval

University of GothenburgORCID 0000-0002-9939-6492Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Andrei S. ChaginiD· 2 shared Claes OhlssoniD· 2 shared Dana TrompetiD· 2 shared Lars S SavendahliD· 2 shared Nelson Tsz Long Chu· 2 shared Xin TianiD· 2 shared Baoyi Zhou· 1 shared Björn BareniusiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCell Biology

Andrei S. ChaginORCID

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2 papers

Recent·Most cited

A transcriptional atlas of the pubertal human growth plate reveals direct stimulation of cartilage stem cells by growth hormone.

Nelson Tsz Long Chu, Ostap A. Dregval, Farasat Zaman, Lei Li, Xin Tian, Xin Liu, Dana Trompet, Baoyi Zhou, Jussi Heinonen, Claes Ohlsson, Lars S Savendahl, Igor I. Adameyko, Andrei S. Chagin

This study reveals GH directly stimulates human growth plate stem cell proliferation via TGF{beta} and ERK pathways, offering insights into growth mechanisms and treatment optimization.

Science Translational Medicine · Apr 15, 2026Peer-reviewedCell Biology

Quantitative Multicolored Deep Imaging of Human Bones Reveals a Composite Osteo-Sinusoidal Niche for Mesenchymal Stromal Cells.

Nelson Tsz Long Chu, Ostap A. Dregval, Yu‐Wei Chang, Emil Kryukov, Xin Tian, Xin Liu, Dana Trompet, Misty Shuo Zhang, Lei Li, Zhong Li, Emiliano Gómez-Ruiz, Joana B. Pereira, Mats Brittberg, Björn Barenius, Lars S Savendahl, , Andrei S. Chagin

The paper uses a tissue-clearing protocol to spatially map BM-MSCs in human bones, revealing distinct microenvironment features in young and aged bones.

bioRxiv · Oct 7, 2025 · PreprintCell Biology