Author

Barbara Leon

Novartis (Switzerland)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Daniel K. NomuraiD· 1 shared Emily Ho· 1 shared Grace ZhouiD· 1 shared Halime Yilmaz· 1 shared Hannah R. Grupe· 1 shared James A. OlzmanniD· 1 shared Lauren M. OrriD· 1 shared Melissa Lim· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Daniel K. NomuraORCID

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1 paper

Recent·Most cited

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

Lauren M. Orr, Sydney J. Tomlinson, Hannah R. Grupe, Melissa Lim, Emily Ho, Halime Yilmaz, Grace Zhou, Barbara Leon, James A. Olzmann, Daniel K. Nomura

This paper identifies a covalent degradative handle that can be transplanted onto various protein-targeting ligands to induce degradation of their targets, enabling modular degrader design.

ACS Central Science · Jun 26, 2025Peer-reviewedBiochemistry