James A. Olzmann

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

This study shows that fatty acid double-bond geometry affects metabolic fate and ferroptosis sensitivity by altering lipid composition and enzyme recognition.

The paper shows liver-targeted copper supplementation reduces steatosis by enhancing lipolysis and fatty acid oxidation through copper-dependent metabolic pathways.

This study identifies vitamin B2 metabolism as a regulator of FSP1 stability, which prevents ferroptosis by maintaining FSP1 function through FAD cofactor binding.

This study identifies CLCC1 as a regulator of hepatic neutral lipid flux and nuclear pore complex assembly through CRISPR screens and functional analyses.

This study shows targeting FSP1 in regulatory T cells disrupts their immunosuppression, enhancing anti-tumor immunity without causing autoimmunity.

This paper demonstrates that ER membrane proteins can be degraded via cytosolic E3 ligase recruitment, bypassing ERAD and relying on VCP-mediated ubiquitin chain cleavage.

This study identifies FSP1 as a critical regulator of lipid droplet quality control, preventing neutral lipid peroxidation and ferroptosis by recycling CoQ10.

This study shows that fatty acid metabolism regulates plasma membrane cholesterol accessibility through ATGL-dependent phospholipid remodeling, affecting membrane fluidity and cholesterol signaling.

This paper identifies a covalent degradative handle that can be transplanted onto various protein-targeting ligands to induce degradation of their targets, enabling modular degrader design.

This paper develops LIPTACs, LDLR-targeting chimeras that enhance lysosomal delivery and cytotoxicity for cancer treatment by combining eTPD and ADC strategies.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

The paper introduces the Lipid Droplet Knowledge Portal, a resource integrating datasets on lipid droplet biology to uncover new determinants of lipid storage.