Lauren M. Orr

This paper develops second-generation acyl silane photoaffinity probes for cellular chemoproteomic profiling, showing improved labeling properties compared to existing diazirine-based probes.

This paper identifies a covalent degradative handle that can be transplanted onto various protein-targeting ligands to induce degradation of their targets, enabling modular degrader design.

This study identifies a covalent handle that enables the degradation of multiple protein targets when appended to protein-targeting ligands.