A microglia clonal inflammatory disorder in Alzheimer's Disease
Rocío Vicario, Stamatina Fragkogianni, Leslie Weber, Tomi Lazarov, Yang Hu, Samantha Y. Hayashi, Barbara P. Craddock, Nicholas D. Socci, Araitz Alberdi, Ann Baako, Oyku Ay, Masato Ogishi, Estibaliz Lopez-Rodrigo, Rajya L. Kappagantula, Agnes J. Viale, , Frédéric Geissmann
The paper identifies microglia-specific somatic clones with pathogenic variants in Alzheimer's Disease patients that drive neuro-inflammation through the MAPK pathway.
eLife · Jan 29, 2025Peer-reviewedNeuroscience