The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

Science Immunology · Nov 7, 2025Peer-reviewedImmunology

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

Adam S. Krebs, Tomi Lazarov, Anthony Reynolds, Kimberly A. Dill‐McFarland, Abigail Xie, James M. Bean, Muxue Du, Olivier Levy, John A. Buglino, Aaron Zhong, Anna‐Lena Neehus, Stéphanie Boisson‐Dupuis, Jean‐Laurent Casanova, Elouise E. Kroon, Marlo Möller, , Michael S. Glickman

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

bioRxiv · Jul 23, 2025 · PreprintImmunology

A microglia clonal inflammatory disorder in Alzheimer's Disease

Rocío Vicario, Stamatina Fragkogianni, Leslie Weber, Tomi Lazarov, Yang Hu, Samantha Y. Hayashi, Barbara P. Craddock, Nicholas D. Socci, Araitz Alberdi, Ann Baako, Oyku Ay, Masato Ogishi, Estibaliz Lopez-Rodrigo, Rajya L. Kappagantula, Agnes J. Viale, , Frédéric Geissmann

The paper identifies microglia-specific somatic clones with pathogenic variants in Alzheimer's Disease patients that drive neuro-inflammation through the MAPK pathway.

eLife · Jan 29, 2025Peer-reviewedNeuroscience