Yang Hu

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.

A microglia clonal inflammatory disorder in Alzheimer's Disease

The paper identifies microglia-specific somatic clones with pathogenic variants in Alzheimer's Disease patients that drive neuro-inflammation through the MAPK pathway.

Mapping of Multilineage Tumor Cell Populations in Mouse Bladder Cancer

This study uses deep learning and reference atlases to analyze tumor cell populations in mouse bladder cancer, identifying lineage-specific subpopulations and their therapeutic vulnerabilities.

Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing

This study uses single-cell RNA sequencing to analyze transcriptional changes in spermatogonia and spermatocytes across developmental stages, revealing age-related gene expression differences and pathway utilization.