Gαq/11 signalling counteracts endothelial dysfunction in the brain and protects cognition in aged mice
Dimitrios Spyropoulos, Lena Kleindienst, Phillip Ehrich, Dorothea Ziemens, Rentsenkhand Natsagdorj, Nicholas Noll, Cathrin Elly Hansen, Géza Adam Curley, Anne-Sophie Gutt, Ákos Menyhárt, Jan Sedlacik, Peter Ludewig, Beate Lembrich, Ümit Özorhan, Evi Kostenis, , Jan Wenzel
This study shows that Gαq/11 signaling in brain endothelial cells prevents endothelial dysfunction and cognitive decline in aged mice by maintaining vascular reactivity and preventing blood-brain barrier disruption.
EBioMedicine · May 18, 2026Peer-reviewedNeuroscience