Evi Kostenis

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

This study shows Gβγ enhances PLCβ3 activation by reorienting its catalytic site, working with Gq to increase PI(4,5)P2 hydrolysis and Ca2+ release.

This study shows that Gαq/11 signaling in brain endothelial cells prevents endothelial dysfunction and cognitive decline in aged mice by maintaining vascular reactivity and preventing blood-brain barrier disruption.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

This study develops a fluorescent ligand to identify improved antagonists targeting the intracellular allosteric site of CCR7, showing their effectiveness in both recombinant and endogenous settings.

This paper introduces a label-free optical biosensor assay to study TLR signaling dynamics and identifies pharmacological modulators and previously unrecognized signaling signatures.

The paper shows that intron retention generates single transmembrane-helix isoforms of aGPCRs, enabling mechanosensory function through heteromerization with 7TM subunits.

This study shows psilocin excites 5-HT2A Layer 5 Pyramidal Neurons in the mouse PFC via a Gq-mediated mechanism, increasing firing without affecting synaptic transmission.

This study demonstrates that melanopsin-expressing ganglion cells in fetal mouse retinas are light-responsive and identify the transduction pathways involved.