Tau catalyzes amyloid-β aggregation in a fold-dependent manner
Michele Mosconi, Chiara Leonardi, Zev Armour-Garb, Beatrice Rocutto, Marten Beeg, Georg Meisl, Lei Ortigosa-Pascual, Luca Broggini, Mario Salmona, Stéfano Ricagno, Tuomas P. J. Knowles, Luisa Diomede
This study shows tau proteins from Alzheimer's and CTE folds catalyze Aβ42 aggregation in a fold-specific manner, increasing toxicity and offering new therapeutic insights.
bioRxiv · Oct 21, 2025 · PreprintBiochemistry