Mario Salmona

This study investigates the effects of HDAC inhibition and its combination with arimoclomol on TDP-43 proteinopathy in vitro and in vivo, finding delayed pathology and synergistic neuroprotection.

This study shows tau proteins from Alzheimer's and CTE folds catalyze Aβ42 aggregation in a fold-specific manner, increasing toxicity and offering new therapeutic insights.

This study develops a C. elegans model expressing a human amyloidogenic light chain to study cardiac tropism in AL amyloidosis, finding pharyngeal impairment and oxidative stress similar to human cardiac disease.

Chronic cholesterol delivery via brain-permeable nanoparticles improves cognitive and motor function and reduces mutant Huntingtin aggregates in HD mice.

This study evaluates hybrid nanoparticles for delivering cholesterol to the brain in Huntington disease, showing improved targeting, controlled release, and therapeutic benefits without inflammation.