Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
Rebecca Andrews, Bin Fu, Christina E. Toomey, Jonathan C. Breiter, Joanne Lachica, Joseph S. Beckwith, Ru Tian, Emma E. Brock, Lisa-Maria Needham, Gregory J. Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, , Steven F. Lee
This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.
Nature Biomedical Engineering · Oct 1, 2025Peer-reviewedNeuroscience