Gregory J. Chant

This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.

This study uses 3D super-resolution microscopy to analyze PSD95 nanoarchitecture in the mouse brain, revealing diffuse supercomplexes outside synapses and distinct subtypes within synapses.