Author

Emma E. Brock

University of CambridgeORCID 0000-0002-7683-0153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:imaging· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Jonathan C. BreiteriD· 4 shared Joseph S. BeckwithiD· 4 shared Steven F. LeeiD· 4 shared Bin FuiD· 3 shared Christina E. ToomeyiD· 3 shared Joanne LachicaiD· 3 shared Michele VendruscoloiD· 3 shared Mina RyteniD· 3 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Jonathan C. BreiterORCID

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4 papers

Recent·Most cited

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

Rebecca Andrews, Bin Fu, Christina E. Toomey, Jonathan C. Breiter, Joanne Lachica, Joseph S. Beckwith, Ru Tian, Emma E. Brock, Lisa-Maria Needham, Gregory J. Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin, Rebeka Popovic, James Evans, , Steven F. Lee

This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.

Nature Biomedical Engineering · Oct 1, 2025Peer-reviewedNeuroscience

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.

Matthew W. Cotton, Shriram Venkatesan, Joseph S. Beckwith, Dorothea Böken, Catherine K. Xu, Emre Fertan, Jonathan C. Breiter, Lexie E. Berkowicz, Laura Sancho Salazar, Alex T. Von Schulze, Ewa A. Andrzejewska, Emma E. Brock, Hannah L. Han, Matthias M. Schneider, Danny D. Sahtoe, , Georg Meisl

The paper identifies a cellular tipping point between aggregate accumulation and removal as a universal feature of neurodegeneration, validated through live-cell assays and super-resolution imaging.

bioRxiv · Sep 8, 2025 · PreprintNeuroscience

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease

James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith, Christina E. Toomey, Rebeka Popovic, Jonathan C. Breiter, Jonathan Brenton, Aine Fairbrother-Browne, Stephanie Strohbuecker, Joanne Lachica, Maria Rodríguez‐López, Emma E. Brock, Bin Fu, Leila Nahidiazar, Patricia Lopez-Garcia, , Sonia Gandhi

The paper identifies microglial activation and alpha-synuclein oligomers as drivers of early neuroinflammation in Parkinson's disease using transcriptomic and aggregate profiling in early-stage brain samples.

bioRxiv · Aug 25, 2025 · PreprintNeuroscience

α-Synuclein driven cell susceptibility in Parkinson's disease

Jonathan C. Breiter, Joseph S. Beckwith, Emma E. Brock, Joanne Lachica, Christina E. Toomey, Bin Fu, Mina Ryten, Lucien E. Weiss, Nicholas W. Wood, Sonia Gandhi, Michele Vendruscolo, Steven F. Lee

The paper maps α-synuclein oligomers in Parkinson's disease brain tissue to identify aggregation-susceptible cells and proposes a population-level model for early pathology.

bioRxiv · Aug 19, 2025 · PreprintNeuroscience