Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs
Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan M. Howard, Jan Felix Dalwigk, Reza Maroofian, Stéphanie Efthymiou, Patricia P. Chan, Sergei I. Eliseev, Zi F. Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie Kaiser, , Dragony Fu
The paper identifies the roles of TRMT1 and TRMT1L in tRNA modifications, showing their impact on tRNA stability and function, and links TRMT1 variants to disease.
Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology