Author

Jan Felix Dalwigk

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Approach:benchmark study· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:metagenomics· 1

Frequent Co-Authors

Stefanie KaiseriD· 3 shared Kira Kerkhoff· 2 shared Michael S. DeMottiD· 2 shared Oskar Knittelfelder· 2 shared Patrick A. LimbachiD· 2 shared Peter C. DedoniD· 2 shared Philippe Wolff· 2 shared Robert L. RossiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMolecular Biology

Stefanie KaiserORCID

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Author profile →

3 papers

Recent·Most cited

Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification

Jan Felix Dalwigk, Kira Kerkhoff, Oskar Knittelfelder, Robert L. Ross, Maria Cristina Petrella, Anna Kuśnierczyk, Tulsi Bhandari, Aurore Attina, Alicia Burkard, Carolina Brás Costa, Michael S. DeMott, K J. Johnson, Xenia Kerkhoff-Bernaciak, Jennifer Kist, Ken Kögel, , Stefanie Kaiser

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

bioRxiv · Jul 23, 2026 · PreprintGenomics

Human 28S rRNA analysed by state-of-the-art oligonucleotide mass spectrometry: benchmarking current capabilities and a call to action for MS-Seq

Jannick Schicktanz, Ying Qi, Junzhou Wu, Bibek Hamal, Antony Lechner, Sam Wein, Oskar Knittelfelder, Nur Yeşiltaç-Tosun, Jan Felix Dalwigk, Katharina Hoja, Leona A. Rusling, Sofia Obersteiner, Ella Bellenberg, Kira Kerkhoff, Michael S. DeMott, , Stefanie Kaiser

The paper benchmarks MS-Seq for human 28S rRNA analysis, showing reproducible results across platforms but highlighting gaps in coverage and ambiguity.

bioRxiv · Jul 17, 2026 · PreprintMolecular Biology

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan M. Howard, Jan Felix Dalwigk, Reza Maroofian, Stéphanie Efthymiou, Patricia P. Chan, Sergei I. Eliseev, Zi F. Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie Kaiser, , Dragony Fu

The paper identifies the roles of TRMT1 and TRMT1L in tRNA modifications, showing their impact on tRNA stability and function, and links TRMT1 variants to disease.

Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology