Aidan C. Manning

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

The paper introduces RiboMarker, a method for comprehensive sRNA sequencing that detects all RNA fragment types, improving sensitivity for low-abundance biomarkers.

This study examines tRNA and tRNA-derived RNA (tDR) expression and modification across 19 mouse tissues, revealing tissue-specific patterns and regulatory mechanisms.

This study shows that gammaherpesvirus infection leads to tRNA cleavage, producing tRNA fragments that are regulated by tRNA splicing factors and essential for viral replication.

This study characterizes transcriptomic changes in Coccidioides posadasii across different morphologies using RiboMarker-enhanced RNA sequencing, revealing small RNA and fragment expression patterns associated with life stage transitions.

The paper identifies the roles of TRMT1 and TRMT1L in tRNA modifications, showing their impact on tRNA stability and function, and links TRMT1 variants to disease.

This study investigates the distinct roles of ADAR-1 and ADAR-2 in C. elegans by analyzing their effects on RNA editing, gene expression, and phenotypes when mutated individually.