A stress-dependent TRIM28-ALKBH2 feedback loop modulates chemoresistance in NSCLC
Zhiming Sun, Yunfang Deng, Yue Liu, Zhaohui Liu, Jiabing Li, Lihui Wu, Liyuan Zeng, Xiaorong Feng, Lin Miao, Ying Sheng, Bei Chen, Yuming He, Ye Liu, Yu Zhao
This study identifies a stress-dependent TRIM28-ALKBH2 feedback loop that modulates chemoresistance in NSCLC by regulating DNA repair and alkylation tolerance.
bioRxiv · Nov 21, 2025 · PreprintBiochemistry