Every Piece of the Puzzle Matters: A Novel Zinc-Binding Site in the Luminal Domain of STIM1 Drives Clustering
Benedicte Alary, Viktoriia E. Baksheeva, Sabrina Beaumier, Géraldine Ferracci, Claude Villard, Andrey V. Golovin, Sébastien Courrier, François Devred, Marc Bartoli, Philipp O. Tsvetkov
The paper identifies a zinc-binding site in the luminal domain of STIM1 that promotes clustering and is essential for calcium influx activation.
bioRxiv · Jun 12, 2025 · PreprintBiochemistry