Philipp O. Tsvetkov

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

The paper introduces a nanoDSF method to screen for anti-tubulin compounds, identifying novel MTAs among approved drugs and demonstrating its effectiveness in detecting known and new agents.

The paper identifies a zinc-binding site in the luminal domain of STIM1 that promotes clustering and is essential for calcium influx activation.

This study identifies three zinc-binding sites on the Tau protein using NMR and molecular simulations, providing insights into zinc-induced aggregation mechanisms and potential therapeutic targets.

This study shows APOE4 promotes inflammation in human astrocytes by repressing TAGLN3 through HDAC activity, linking it to Alzheimer's disease pathology.