François Devred

The paper introduces a nanoDSF method to screen for anti-tubulin compounds, identifying novel MTAs among approved drugs and demonstrating its effectiveness in detecting known and new agents.

The paper identifies a zinc-binding site in the luminal domain of STIM1 that promotes clustering and is essential for calcium influx activation.

This study identifies three zinc-binding sites on the Tau protein using NMR and molecular simulations, providing insights into zinc-induced aggregation mechanisms and potential therapeutic targets.

This study shows APOE4 promotes inflammation in human astrocytes by repressing TAGLN3 through HDAC activity, linking it to Alzheimer's disease pathology.