The UTX Tumor Suppressor Directly Senses Oxygen to Control Chromatin and Cell Fate
Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Y. Tolstorukov, Yuzhong Jeff Meng, Sam Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Jessica Spinelli, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, , William G. Kaelin
The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.
bioRxiv · Jan 3, 2019 · PreprintBiochemistry