William G. Kaelin

The paper screens natural products to identify β-catenin inactivators, finding one that activates novel PKCs and relocates β-catenin to juxtamembrane vacuolar structures.

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

The paper shows that KDM6A, an H3K27 histone demethylase, is oxygen-sensitive and its inactivation under hypoxia affects chromatin and cell fate.