Drug Combination Antagonism and Single Agent Dominance Result from Differences in Death Activation Kinetics
Ryan Richards, Hannah R. Schwartz, Mariah S. Stewart, Peter Cruz‐Gordillo, Megan E. Honeywell, Anna J. Joyce, Benjamin D. Landry, Michael J. Lee
The paper identifies antagonistic drug interactions in cancer therapy by analyzing death activation kinetics, finding that single agent dominance occurs due to differences in cell death onset time.
bioRxiv · Oct 16, 2019 · PreprintSystems Biology