Ryan Richards

Drug GRADE: an integrated analysis of population growth and cell death reveals drug- specific and cancer subtype-specific response profiles

This study quantifies drug-induced growth inhibition and cell death using live/dead cell counting and introduces drug GRADE to analyze their relationship, revealing drug- and genotype-specific responses.

Drug Combination Antagonism and Single Agent Dominance Result from Differences in Death Activation Kinetics

The paper identifies antagonistic drug interactions in cancer therapy by analyzing death activation kinetics, finding that single agent dominance occurs due to differences in cell death onset time.