Author

Anna J. Joyce

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Hannah R. SchwartziD· 2 shared Megan E. HoneywelliD· 2 shared Michael J. LeeiD· 2 shared Ryan Richards· 2 shared Benjamin D. Landry· 1 shared Mariah S. StewartiD· 1 shared Peter Cruz‐GordilloiD· 1 shared Rachel E. Fontana· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersSystems Biology

Hannah R. SchwartzORCID

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2 papers

Recent·Most cited

Drug GRADE: an integrated analysis of population growth and cell death reveals drug- specific and cancer subtype-specific response profiles

Hannah R. Schwartz, Ryan Richards, Rachel E. Fontana, Anna J. Joyce, Megan E. Honeywell, Michael J. Lee

This study quantifies drug-induced growth inhibition and cell death using live/dead cell counting and introduces drug GRADE to analyze their relationship, revealing drug- and genotype-specific responses.

Cell Reports · Jun 1, 2020Peer-reviewedSystems Biology

Drug Combination Antagonism and Single Agent Dominance Result from Differences in Death Activation Kinetics

Ryan Richards, Hannah R. Schwartz, Mariah S. Stewart, Peter Cruz‐Gordillo, Megan E. Honeywell, Anna J. Joyce, Benjamin D. Landry, Michael J. Lee

The paper identifies antagonistic drug interactions in cancer therapy by analyzing death activation kinetics, finding that single agent dominance occurs due to differences in cell death onset time.

bioRxiv · Oct 16, 2019 · PreprintSystems Biology