O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis
Oumaima Ahmed, Louis Masclef, Nicholas Iannantuono, Jessica K. Gagnon, Mila Gushul-Leclaire, Karine Boulay, Benjamin Estavoyer, Mohamed Echbicheb, Kalidou Ali Boubacar, Marty Poy, Amina Boubekeur, Saad Menggad, Alejandro Schcolnik‐Cabrera, Aurélio Balsalobre, Éric Bonneil, , El Bachir Affar
This study shows FOXK1 O-GlcNAcylation regulates the E2F pathway, promoting cell proliferation and oncogenesis by modulating chromatin structure and transcriptional activity.
Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology