Jacques Drouin

The paper shows PAX7 acts in two chromatin compartments, with distinct mechanisms and biological outcomes during pituitary development.

This study identifies BDNF as a key signal for pituitary stem cell differentiation and homeostasis in mouse models of glucocorticoid deficiency.

This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.

This study shows FOXK1 O-GlcNAcylation regulates the E2F pathway, promoting cell proliferation and oncogenesis by modulating chromatin structure and transcriptional activity.

This study identifies the sequence of events by which the pioneer factor Pax7 initiates chromatin opening through cell-cycle dependent mechanisms.

This study investigates the structural requirements of Pax7 for chromatin interaction and opening, showing that specific isoforms and C-terminal domains are essential for its pioneer factor function.

This study shows that Pax7's pioneer action on heterochromatin requires both DNA binding domains, while low affinity binding only needs the paired domain.

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.

The paper shows that pioneer factor Pax7 and nonpioneer factor Tpit cooperate to open chromatin in melanotrope cells, with Pax7 recognizing heterochromatin and Tpit enabling chromatin opening.

This study identifies Creb3l2 as a transcription factor that scales translation capacity in secretory cells by directly regulating translation effector genes.