Éric Bonneil

Mice with mono-allelic p.R37H Dhdds variant show aberrant glycosylation and interneuron deficits

This study describes a mouse model of DHDDS-CDG, showing seizures, myoclonus, and cognitive deficits linked to glycosylation defects and interneuron abnormalities.

STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation.

The paper shows STING dampens the unfolded protein response to allow self-antigen presentation on MHC-I during inflammation, linking it to immune regulation in Parkinson's disease.

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

Redundant roles of YES and SRC tyrosine kinases in driving malignant peripheral nerve sheath tumors

This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.

IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies

This study shows that IRP1 deficiency in mice leads to metabolic changes that protect against metabolic syndrome by altering mitochondrial function and improving insulin sensitivity.

O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis

This study shows FOXK1 O-GlcNAcylation regulates the E2F pathway, promoting cell proliferation and oncogenesis by modulating chromatin structure and transcriptional activity.

Enriching for Extracellular Vesicles from Human Bone

This study introduces a new protocol to isolate and enrich extracellular vesicles from human trabecular bone and bone marrow without enzymatic digestion or long-term culture.

Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1.

Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis

This study identifies Ankle2 as a regulatory subunit of PP2A that promotes BAF dephosphorylation and nuclear reassembly by interacting with Vap33 during telophase.

Comprehensive Proteomic Analysis of HCoV-OC43 Virions and Virus-Modulated Extracellular Vesicles

This study identifies host proteins incorporated into HCoV-OC43 virions and virus-modulated extracellular vesicles, revealing their roles in viral spread and extracellular vesicle composition.

p38γ and p38δ modulate innate immune response by regulating MEF2D activation

This study shows that p38γ and p38δ regulate innate immune responses by modulating MEF2D phosphorylation and transcriptional activity in mice.

SPAT: Surface Protein Annotation Tool

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

Immunopeptidomics for Dummies: Detailed Experimental Protocols and Rapid, User-Friendly Visualization of MHC I and II Ligand Datasets with MhcVizPipe

The paper provides detailed experimental protocols and an open-source tool, MhcVizPipe, for analyzing MHC I and II ligand datasets in immunopeptidomics.

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.