Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy
Asli E. Atici, Prasant Kumar Jena, Thacyana Teixeira de Carvalho, Benjamin L. Ross, Emily A. Aubuchon, Malcolm E. Lane, Angela C. Gomez, Youngho Lee, Shuang Chen, Timothy R. Crother, Moshe Arditi, Magali Noval Rivas
This study shows that SIRT1 activation reduces vasculitis severity in a murine model of Kawasaki disease by enhancing autophagy and mitophagy.
bioRxiv · Sep 4, 2025 · PreprintImmunology