Author

Shuang Chen

University of MichiganORCID 0000-0002-6879-7285Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Shuang Chen2 papers · China Pharmaceutical University

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Jie XuiD· 2 shared Jun ZhouiD· 2 shared Xiaofeng XiaiD· 2 shared Xiaoqiang HuangiD· 2 shared Y. Eugene CheniD· 2 shared Angela C. GomeziD· 1 shared Asli E. AticiiD· 1 shared Benjamin L. Ross· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Jie XuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

Youcai Xiong, Li-Kuang Tsai, Jun Zhou, Shuang Chen, Xiaofeng Xia, Jifeng Zhang, Y. Eugene Chen, Jie Xu, Xiaoqiang Huang

This paper computationally designs a PAM-relaxed SaCas9 variant, KRH, with expanded targeting capability and enhanced editing efficiency.

eLife · Apr 24, 2026Peer-reviewedBioengineering

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy

Asli E. Atici, Prasant Kumar Jena, Thacyana Teixeira de Carvalho, Benjamin L. Ross, Emily A. Aubuchon, Malcolm E. Lane, Angela C. Gomez, Youngho Lee, Shuang Chen, Timothy R. Crother, Moshe Arditi, Magali Noval Rivas

This study shows that SIRT1 activation reduces vasculitis severity in a murine model of Kawasaki disease by enhancing autophagy and mitophagy.

bioRxiv · Sep 4, 2025 · PreprintImmunology

Fast, accurate parsing of antibody structures and antibody-antigen interactions enables a comprehensive structural antibody database

Xiaoqiang Huang, Jun Zhou, Shuang Chen, Xiaofeng Xia, Y. Eugene Chen, Jie Xu

The paper introduces SAAINT-parser, a tool for extracting antibody and antibody-antigen interaction data from PDB, resulting in SAAINT-DB, which offers more accurate and comprehensive data than existing databases.

Acta Pharmacologica Sinica · Jun 30, 2025Peer-reviewedBioinformatics