Moshe Arditi

Spatial profiling of Kawasaki disease cardiac inflammation identifies STING as a therapeutic target

This study identifies STING as a therapeutic target for Kawasaki disease by analyzing spatial immune architecture in cardiac inflammation.

Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina

The paper identifies Chlamydia pneumoniae infection and NLRP3 inflammasome activation in Alzheimer's disease retinas, linking them to disease progression and cognitive impairment.

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy

This study shows that SIRT1 activation reduces vasculitis severity in a murine model of Kawasaki disease by enhancing autophagy and mitophagy.

Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

This study shows that hypothermia reduces IL-1β release and NETs formation in LPS-HVV-induced lung injury, preventing hypoxemia and acute respiratory failure.

The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice.

This study shows that gut microbiota depletion reduces cardiovascular inflammation in a mouse model of Kawasaki disease, and specific bacteria or their metabolites can alleviate vasculitis by improving gut barrier function.

Impact of South African 501.V2 Variant on SARS-CoV-2 Spike Infectivity and Neutralization: A Structure-based Computational Assessment

Modeling indicates N501Y strengthens ACE2 binding while K417N and E484K break two interface salt bridges, leaving 501.V2 affinity near wildtype but weakening several monoclonal antibodies.