Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients
Manuel Johanns, Joel T. Haas, Violeta Raverdy, Jimmy Vandel, Julie Chevalier-Dubois, Loïc Guille, Bruno Derudas, Benjamin Legendre, Robert J. Caiazzo, Hélène Verkindt, Viviane Gnemmi, Emmanuelle Leteurtre, Mehdi Derhourhi, Amélie Bonnefond, Philippe Froguel, , Philippe Lefèbvre
The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.
bioRxiv · Apr 5, 2023 · PreprintGenomics