Amélie Bonnefond

The paper investigates the role of FXR signaling in hepatic stellate cells (HSCs) during liver homeostasis and fibrosis, showing its impact on gene expression and anti-fibrotic effects.

This study shows flagellin activates TLR5 in human airway epithelium, enhancing immune responses in both healthy and diseased states, but not directly reducing bacterial load.

The paper develops a deep learning model combining clinical data, gene expression, and DNA methylation to distinguish NASH from steatosis and identifies new genes involved in liver disease severity.

The paper identifies genetic clusters underlying T2D and hypertension comorbidity using partitioned polygenic scores, improving risk prediction for individuals with heightened susceptibility.

This study identifies biallelic SREK1 variants causing a Prader-Willi-like syndrome with obesity and hypotonia in consanguineous children.

The paper introduces a framework for time-varying GWAS to identify age-varying genetic effects on BMI across childhood, finding 28 genome-wide significant variants, including a novel one in DAOA.

The paper identifies shared genetic regulation across mRNA, proteins, and metabolites in blood, revealing networks and mediators of GWAS variants.

This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

The paper identifies hypermethylation of PNLIPRP1 in T2D patients and shows its association with acinar-to-ductal metaplasia and PDAC risk.

This study examines DNA methylation changes linked to hyperglycaemia exposure in a longitudinal cohort over six years but finds no robust associations reaching FDR significance.

This study shows BIN1 regulates L-type calcium channels in neurons, affecting calcium homeostasis and electrical activity, and links these changes to Alzheimer's disease pathology.

This study shows that BIN1 isoform1 causes early endosome defects and neurodegeneration in Drosophila and human neurons, linking it to Alzheimer's disease pathology.

The paper links DNA methylation changes in HSCs from large for gestational age neonates to altered quiescence via transcriptional network disruption.

This study identifies three new susceptibility genes for calcific aortic valve stenosis through GWAS and TWAS, highlighting roles in inflammation, mineralization, and blood vessel integrity.