Jérôme Eeckhoute

Hepatic stellate cell FXR signaling regulates context-dependent functions in liver homeostasis and fibrosis.

The paper investigates the role of FXR signaling in hepatic stellate cells (HSCs) during liver homeostasis and fibrosis, showing its impact on gene expression and anti-fibrotic effects.

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ϵ/REV-ERBα/Transgelin Signaling Pathway.

This study identifies a circadian clock-controlled signaling pathway that drives hepatic stellate cell activation in liver fibrosis, offering potential drug targets and a basis for chronotherapeutic strategies.

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming

This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patients

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

A time- and space-resolved nuclear receptor atlas in mouse liver

This paper maps nuclear receptor expression in mouse liver across time and space using single-cell RNAseq data.

Model-based Analysis of ChIP-Seq (MACS)

MACS calls ChIP-Seq peaks by estimating tag shift from Watson/Crick strand offsets and testing enrichment against a locally adaptive Poisson background, improving specificity and binding-site resolution.