Cigarette Smoke and Decreased DNA Repair by Xeroderma Pigmentosum Group C Use a Double Hit Mechanism for Epithelial Cell Lung Carcinogenesis
Nawar Al Nasrallah, Bowa Lee, Benjamin M. Wiese, Marie Nour Karam, Elizabeth A. Mickler, Huaxin Zhou, Nicki Paolelli, Robert S. Stearman, Mark W. Geraci, Catherine R. Sears
This study shows that reduced XPC expression and cigarette smoke exposure together cause DNA damage and apoptosis in bronchial epithelial cells, contributing to COPD and NSCLC through a 'double hit' mechanism.
Oncotarget · May 20, 2025Peer-reviewedCancer Biology