Robert S. Stearman

Cigarette Smoke and Decreased DNA Repair by Xeroderma Pigmentosum Group C Use a Double Hit Mechanism for Epithelial Cell Lung Carcinogenesis

This study shows that reduced XPC expression and cigarette smoke exposure together cause DNA damage and apoptosis in bronchial epithelial cells, contributing to COPD and NSCLC through a 'double hit' mechanism.

Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension

The paper identifies a gene co-expression module, the pink module, associated with PAH severity, genetic risk, vascular cell types, and therapeutic targets through multiomics integration.