Mark W. Geraci

Cigarette Smoke and Decreased DNA Repair by Xeroderma Pigmentosum Group C Use a Double Hit Mechanism for Epithelial Cell Lung Carcinogenesis

This study shows that reduced XPC expression and cigarette smoke exposure together cause DNA damage and apoptosis in bronchial epithelial cells, contributing to COPD and NSCLC through a 'double hit' mechanism.

Integrative genetic and genomic networks identify microRNA associated with COPD and ILD

The paper identifies miRNAs and isomiRs associated with COPD and ILD through integrative network analysis of RNA-seq and SNP data from lung tissue samples.

Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension

The paper identifies a gene co-expression module, the pink module, associated with PAH severity, genetic risk, vascular cell types, and therapeutic targets through multiomics integration.