The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
Adam Duxfield, Rebecca Garnham, Esme Hutton, Adam Dowle, Jamie Wills, Sara Luzzi, Ryan Nelson, Emma Lishman-Walker, Rianna Magee, Adriana Buskin, Anastasia C. Hepburn, Emirhan Tekoglu, Kaidan Maloney-Friar, Fiona M. Frame, Norman J. Maitland, , Emma Scott
This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.
bioRxiv · Oct 15, 2025 · PreprintCancer Biology