Adriana Buskin

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

This paper introduces a high-throughput method to generate human prostate tissue from induced pluripotent stem cells using co-culture with urogenital sinus mesenchyme.

This study shows that AAV-mediated gene augmentation therapy can restore critical functions in PRPF31 mutant iPSC-derived RPE cells, providing proof-of-concept for treating PRPF31-related retinitis pigmentosa.

The paper generates patient-specific retinal organoids and RPE from RP type 11 patients to show PRPF31 mutations cause retinal-specific splicing defects and structural/functional impairments, which are corrected by in situ gene editing.