This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

Cell Reports Methods · Jul 29, 2026Peer-reviewedCell Biology

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

Brian M. Ortmann, Tekle Pauzaite, James A.C. Bertlin, Rachel Seear, Esther Arnaiz, Lukasz W. Marzec, Alexander Handyside, Laura M. Bowker, Sarah E. Barnett, Katherine Harcourt, Salwa Lin, Ahmed M. Salman, Laura Wilson, Adrian Llewellyn Harris, Grant Duncan Stewart, , James A. Nathan

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

Cancer Research · Apr 6, 2026Peer-reviewedCancer Biology

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

Adam Duxfield, Rebecca Garnham, Esme Hutton, Adam Dowle, Jamie Wills, Sara Luzzi, Ryan Nelson, Emma Lishman-Walker, Rianna Magee, Adriana Buskin, Anastasia C. Hepburn, Emirhan Tekoglu, Kaidan Maloney-Friar, Fiona M. Frame, Norman J. Maitland, , Emma Scott

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

bioRxiv · Oct 15, 2025 · PreprintCancer Biology

High-throughput propagation of human prostate tissue from induced-pluripotent stem cells

Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad, Rebecca E. Steele, Omar E. Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E. Crawford, Luke Gaughan, Ian Geoffrey Mills, Simon W. Hayward, Craig N. Robson, Rakesh Heer

This paper introduces a high-throughput method to generate human prostate tissue from induced pluripotent stem cells using co-culture with urogenital sinus mesenchyme.

Stem Cells Translational Medicine · Mar 14, 2020Peer-reviewedDevelopmental Biology