Age-specific Aβ-Tau interactions underlie spatial memory deficits in an APP/PS1 amyloidosis model
Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Vivien Tejsi, Shuoshuo Li, Georgia Mitilineou, Kate L. Lambertsen, Hélène Audrain, David James Brooks, Anne M. Landau, Bente Finsen
This study examines how Aβ and tau interactions affect spatial memory in APP/PS1 mice, finding that memory decline is driven by combined Aβ and tau pathologies.
bioRxiv · Dec 10, 2025 · PreprintNeuroscience