David James Brooks

This study examines how Aβ and tau interactions affect spatial memory in APP/PS1 mice, finding that memory decline is driven by combined Aβ and tau pathologies.

This study shows that SORL1 haploinsufficiency in pigs mimics early AD biomarker changes without neurodegeneration, supporting its role as a causal gene in Alzheimer's disease.

This study shows that tau pathology develops spontaneously in APPswe/PS1ΔE9 mice, demonstrating that amyloidosis is necessary and sufficient to drive tauopathy in familial AD models.

This study uses dynamic 11C-PiB PET to show reduced cerebrospinal fluid clearance in Alzheimer’s disease and multiple sclerosis compared to healthy controls.