This study examines how Aβ and tau interactions affect spatial memory in APP/PS1 mice, finding that memory decline is driven by combined Aβ and tau pathologies.

bioRxiv · Dec 10, 2025 · PreprintNeuroscience

Neonatal Microglia and Their Secretome as Mediators of Brain Repair

Gabriela Łyszczarz, Eydís Sigurðardóttir Schiöth, Anouk Benmamar‐Badel, Dominika Rusin, David Ramonet, Marco Anzalone, Thalissa Caers, Lejla Vahl Becirovic, Kirstine Nolling Jensen, Sanne G. S. Verberk, Fleur Mingneau, Martyna Makowska, Kate Lykke Lambertsen, Amy F. Lloyd, Jerome J. A. Hendriks, Agnieszka Włodarczyk

This study shows neonatal microglia improve brain repair in aged mice through secreted factors, highlighting the potential of early microglial programs for regenerative therapies.

bioRxiv · Sep 21, 2025 · PreprintNeuroscience

Serotonin-2B receptor (5-HT2BR) expression and binding in the brain of ageing APPswe/PS1de9 transgenic mice and in human Alzheimer's disease brain tissue

M Anzalone, Sarmad A. Karam, Sanne R. R. Briting, Sussanne Petersen, Majken Borup Thomsen, Anne Marlene Landau, Bente R. Finsen, Athanasios Metaxas

This study examines 5-HT2BR expression and binding in AD mouse models and human tissue, finding age-related changes in mice and higher levels in AD patients.

bioRxiv · May 30, 2024 · PreprintNeuroscience

Tauopathy in the APPswe/PS1ΔE9 mouse model of familial Alzheimer’s disease

Athanasios Metaxas, Camilla Thygesen, Stefan J. Kempf, M Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne Marlene Landau, Hélène Audrain, Jessica L. Teeling, Sultan Darvesh, David James Brooks, Martin R. Larsen, Bente R. Finsen

This study shows that tau pathology develops spontaneously in APPswe/PS1ΔE9 mice, demonstrating that amyloidosis is necessary and sufficient to drive tauopathy in familial AD models.

Scientific Reports · Oct 31, 2019Peer-reviewedNeuroscience