Unbiased, systematic surfaceome profiling of Acute Leukemia to identify novel immunotherapy targets
Benson M. George, Anna Rodríguez-Pöhnlein, Donavelle J DeCastro, Jennifer Porat, Benyu Zhao, Dinah M. Abeja, Ryan J. Lumpkin, Rebecca J. Metivier, Anna M. Schmoker, Wencke Walter, Torsten Haferlach, Yana Pikman, Katherine Donovan, Kimberly Stegmaier, Eric S. Fischer, , Ryan A. Flynn
The paper presents an unbiased surfaceome atlas of leukemic cell lines, identifying novel surface proteins and discordant gene expression patterns, with CD70 highlighted as a potential therapeutic target in AML.
bioRxiv · Oct 10, 2026 · PreprintMolecular Biology