Jennifer Porat

Unbiased, systematic surfaceome profiling of Acute Leukemia to identify novel immunotherapy targets

The paper presents an unbiased surfaceome atlas of leukemic cell lines, identifying novel surface proteins and discordant gene expression patterns, with CD70 highlighted as a potential therapeutic target in AML.

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

This study shows DNASE1L3 clears surface DNA on B and T cells, and variants in DNASE1L3 are linked to higher surface DNA levels in autoimmune disease.

O-glycosylation contributes to mammalian glycoRNA biogenesis

This study demonstrates that O-glycosylation contributes to sialoglycoRNA biogenesis and shows increased sialylation in ulcerative colitis-derived organoids.

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

The paper identifies acp3U as the site where N-glycans attach to RNA in glycoRNA using rPAL and SWATH-MS.

Crosstalk between the tRNA methyltransferase Trm1 and RNA chaperone La influences eukaryotic tRNA maturation

This study shows that the tRNA methyltransferase Trm1 can promote tRNA functionality without catalytic activity and interacts with La to influence tRNA modification.

The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA

This study shows that Bmc1 and Pof8 promote 2'-O-methylation of U6 snRNA and identify a non-canonical snoRNA guiding this modification.

The methyl phosphate capping enzyme Bin3 is a stable component of the fission yeast telomerase holoenzyme

This study identifies Bin3 as a stable component of the fission yeast telomerase holoenzyme, showing its role in holoenzyme assembly through interactions with Pof8 and TER1.