Torsten Haferlach

This study identifies specific mutational sequences in congenital neutropenia patients that predict leukemic transformation.

The paper presents an unbiased surfaceome atlas of leukemic cell lines, identifying novel surface proteins and discordant gene expression patterns, with CD70 highlighted as a potential therapeutic target in AML.

The paper shows cells use a ternary molecular glue to sense heme, triggering BACH1 degradation and HMOX1 expression to detoxify cytoplasmic heme while sparing mitochondrial heme, revealing a therapeutic vulnerability in AML.

This study identifies a shared trans-acting mechanism in splicing factor mutant cancers that drives retained intron (RI) splicing defects through DDR-induced AMPK-AKT imbalance and SRSF1 hypophosphorylation.

This study shows MECOM represses myeloid differentiation by inhibiting CEBPA, and its overexpression in AML reduces CEBPA levels, maintaining stem cell state.

This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

The paper uses SEUSS to analyze the effects of 115 RUNX1 mutations on RNA profiles in myelogenous leukemia cells, categorizing them into three functional groups.

This study identifies two genome-wide significant susceptibility loci for acute myeloid leukemia through a meta-analysis of GWAS data.

The paper develops robust and accurate classifiers for AML diagnosis using blood gene expression data and machine learning across 12,029 samples from 105 studies.