Author

Dinah M. Abeja

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Eric S. FischeriD· 4 shared Katherine A. DonovaniD· 4 shared Nathanael S. GrayiD· 3 shared Anna M. SchmokeriD· 2 shared Benjamin L. EbertiD· 2 shared Jianwei CheiD· 2 shared Mikolaj Michal SlabickiiD· 2 shared Rebecca J. MetivieriD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiochemistry

Eric S. FischerORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unbiased, systematic surfaceome profiling of Acute Leukemia to identify novel immunotherapy targets

Benson M. George, Anna Rodríguez-Pöhnlein, Donavelle J DeCastro, Jennifer Porat, Benyu Zhao, Dinah M. Abeja, Ryan J. Lumpkin, Rebecca J. Metivier, Anna M. Schmoker, Wencke Walter, Torsten Haferlach, Yana Pikman, Katherine Donovan, Kimberly Stegmaier, Eric S. Fischer, , Ryan A. Flynn

The paper presents an unbiased surfaceome atlas of leukemic cell lines, identifying novel surface proteins and discordant gene expression patterns, with CD70 highlighted as a potential therapeutic target in AML.

bioRxiv · Oct 10, 2026 · PreprintMolecular Biology

Positive Selection Screen Identifies Natural Product β-Catenin Inactivators

Matthew W. Boudreau, Vítor F. Freire, Sophie C. Corbett, Lucero Martínez-Fructuoso, Shilpa R. Shenoy, Wenyu Yu, Rohitesh Kumar, Christopher C. Thornburg, Rhone K. Akee, Brian D. Peyser, Qinqin Jiang, Jennifer Splaine, Jamie L. Pfaff, Dongli Yu, Benjamin C. Chandler, , William G. Kaelin

The paper screens natural products to identify β-catenin inactivators, finding one that activates novel PKCs and relocates β-catenin to juxtamembrane vacuolar structures.

Proceedings of the National Academy of Sciences · Sep 25, 2026Peer-reviewedCancer Biology

Charged Molecular Glue Discovery Enabled by Targeted Degron Display

Zhe Zhuang, Woong Sub Byun, Jakub Chrustowicz, Zuzanna Kozicka, Veronica L. Li, Dinah M. Abeja, Katherine A. Donovan, Sara Sepic, Inchul You, Mikolaj Michal Slabicki, Eric S. Fischer, Stephen M. Hinshaw, Benjamin L. Ebert, Brenda Arlene Schulman, Nathanael S. Gray

The paper discovers a charged molecular glue, c-Glue, through targeted degron display, enabling the development of Molecular Glue Degraders (MGDs) for protein degradation.

Nature Chemical Biology · Apr 6, 2026Peer-reviewedBiochemistry

Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics

Kheewoong Baek, Rebecca J. Metivier, Shourya S. Roy Burman, Jonathan W. Bushman, Hojong Yoon, Ryan J. Lumpkin, Julia K. Ryan, Dinah M. Abeja, Megha Lakshminarayan, Hong Yue, Samuel Ojeda, Yuan Xiong, Jianwei Che, Alyssa L. Verano, Anna M. Schmoker, , Eric S. Fischer

The paper identifies 298 protein targets of CRBN-binding molecular glues using a high-throughput affinity purification mass spectrometry workflow and demonstrates a lead compound for the new target PPIL4.

Nature Communications · Jul 24, 2025Peer-reviewedCancer Biology

Discovery of electrophilic degraders that exploit SNAr chemistry

Zhe Zhuang, Woong Sub Byun, Zuzanna Kozicka, Brendan G. Dwyer, Katherine A. Donovan, Zixuan Jiang, Hannah M. Jones, Dinah M. Abeja, Meredith Nicole Nix, Jianing Zhong, Mikolaj Michal Slabicki, Eric S. Fischer, Benjamin L. Ebert, Nathanael S. Gray

This study develops electrophilic degraders using SNAr chemistry, enabling selective protein degradation without requiring a defined E3 ligase recruiter.

bioRxiv · Sep 25, 2024 · PreprintBiochemistry