Short chain fatty acids potentiate azoles by reprogramming fungal acetyl-CoA metabolism
Christopher McCrory, Sofya Rabinovich, Harshini Weerasinghe, Tricia L. Lo, Angavai Swaminathan, Calvin A. Kraupner-Taylor, Traude Helene Beilharz, Berman Judith, Ana Traven
This study shows that short chain fatty acids (SCFAs) increase susceptibility of Candida albicans to fluconazole by reprogramming acetyl-CoA metabolism and reducing ergosterol biosynthesis.
bioRxiv · Jun 30, 2026 · PreprintMicrobiology