Traude Helene Beilharz

Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivation

The paper identifies SCAF4-CPA and KHDRBS1/SAM68 as key regulators of RNAPII termination under CDK12 inactivation, showing termination dynamics influence elongation rate and response to inhibition.

Short chain fatty acids potentiate azoles by reprogramming fungal acetyl-CoA metabolism

This study shows that short chain fatty acids (SCFAs) increase susceptibility of Candida albicans to fluconazole by reprogramming acetyl-CoA metabolism and reducing ergosterol biosynthesis.

The transcriptomic signature of age and sex is not conserved in human primary myocytes

The study compares the transcriptomic profiles of human muscle biopsies and their derived primary myocytes, finding minimal retention of age and sex-related gene expression patterns in culture.

The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking

The paper maps alternative polyadenylation changes during EMT in human mammary epithelial cells and identifies QKI's role in regulating APA and gene expression.

Primary human myoblasts display only minor alternative polyadenylation compared to the transformed C2C12 model of muscle differentiation

The paper compares alternative polyadenylation in primary human myoblasts and C2C12 cells during differentiation, finding less alternative polyadenylation in human cells.

A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism

The paper identifies a splice-altering variant in KLHL40 causing milder NEM8, showing it leads to reduced mRNA and protein expression through aberrant splicing.

Topconfects: a package for confident effect sizes in differential expression analysis provides improved usability ranking genes of interest

Topconfects ranks differentially expressed genes by confident log fold change effect sizes, improving biological interpretation over p-value-based rankings.

Widespread cytoplasmic polyadenylation programs asymmetry in the germline and early embryo

The paper identifies GLD-2 mediated cytoplasmic polyadenylation targets in C. elegans and shows CCF-1 as the major deadenylase for maternal mRNA silencing.